When an employee has handed in their resignation, if their being retrenched, if they have been terminated by the company or if they have unfortunately passed away - you will need to end employment on the system in order to terminate the employee.
NOTE: You will need to add and fill in the final payments that needs to be paid to the employee on the payslip first.
From the Sage Business Cloud Payroll (SBCP) Homescreen:


NOTE: It is possible that you can terminate an employee in a previous period, if you choose to do so please ensure that you have zero'd out all of the values in the current periods payslip.